Energy metabolism
gluconeogenesis and oxidative phosphorylation
DOI:
https://doi.org/10.31686/ijier.vol8.iss9.2643Keywords:
Gluconeogenesis, Oxidative phosphorylation, MetabolismAbstract
Most animal cells are able to meet their energy needs from the oxidation of various types of compounds: sugars, fatty acids, amino acids, but some tissues and cells of our body depend exclusively on glucose and the brain is the largest consumer of all. That is why the body has mechanisms in order to keep glucose levels stable. As it decreases, the degradation of hepatic glycogen occurs, which maintains the appropriate levels of blood glucose allowing its capture continues by those tissues, even in times of absence of food intake. But this reserve is limited, so another metabolic pathway is triggered for glucose production, which occurs in the kidneys and liver and is called gluconeogenesis, which means the synthesis of glucose from non-glucose compounds such as amino acids, lactate, and glycerol. Most stages of glycolysis use the same enzymes as glycolysis, but it makes the opposite sense and differs in three stages or also called deviations: the first is the conversion of pyruvate to oxaloacetate and oxaloacetate to phosphoenolpyruvate. The second deviation is the conversion of fructose 1,6 biphosphate to fructose 6 phosphate and the third and last deviation is the conversion of glucose 6 phosphate to glucose.
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DEVLIN, T. M. Manual of Biochemistry with Clinical Correlations. America: Edgard Blucher Ltda, 1998.
EXTON, J.H. Gluconeogenesis. Metabolism, v. 21, n. 10, p. 945-990, 1972.
HATTING, Maximilian et al. Insulin regulation of gluconeogenesis. Annals of the New York Academy of Sciences, v. 1411, n. 1, p. 21, 2018.
HEMS, R. et al. Gluconeogenesis in the perfused rat liver. Biochemical Journal, v. 101, n. 2, p. 284-292, 1966.
MADIRAJU, Anila K. et al. Metformin inhibits gluconeogenesis via the redox-dependent mechanism in vivo. Nature medicine, v. 24, n. 9, p. 1384-1394, 2018.
MARZZOCO, A.; TORRES, B. B. Basic biochemistry. Rio de Janeiro: Guanabara Koogan, 2007.
NELSON, D. L.; COX, M. M. Lehninger's principles of biochemistry. São Paulo: Sarvier, 2002.
PERRY, Rachel J. et al. Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis. Nature, v. 579, n. 7798, p. 279-283, 2020.
YAN, Hui et al. Estrogen improves insulin sensitivity and suppresses gluconeogenesis via the transcription factor Foxo1. Diabetes, v. 68, n. 2, p. 291-304, 2019.
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Copyright (c) 2020 Luis Henrique Almeida Castro, Leandro Rachel Arguello, Nelson Thiago Andrade Ferreira, Geanlucas Mendes Monteiro, Jessica Alves Ribeiro, Juliana Vicente de Souza, Sarita Baltuilhe dos Santos, Fernanda Viana de Carvalho Moreto, Ygor Thiago Cerqueira de Paula, Vanessa de Souza Ferraz, Tayla Borges Lino, Thiago Teixeira Pereira
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Accepted 2020-08-28
Published 2020-09-01
